The European Partnership on Animal Health and Welfare (represented by the abbreviation EUP AH&W or its acronym EUPAHW) is by far the most ambitious research and innovation initiative the European Commission (EC) has funded to control infectious diseases of animals, and to promote animal welfare. Launched this year (2024), the innovative Partnership is anticipated to invest €360 million over seven years to boost research and facilitate cooperation between all actors. The scope goes beyond the animal health and welfare actors to enhance cross sector collaboration and, through a One Health and One Welfare approach, to provide societal impact. The objectives of the EUP AH&W align with the European Green Deal and its associated Farm to Fork strategy for a fair, healthy, and environmentally friendly food system.The ambitious objectives of the EUP AH&W have attracted a diverse pool of partners, including 56 leading research performing organisations and 30 funding organisations in Europe. The budget is 50% funded by the Horizon Europe Framework Programme for Research and Innovation, and 50% by the EUP AH&W partner institutions/organisations. To date, the Partnership has brought together 90 entities (research-performing institutions, funding organisations, and ministries), including European Food Safety Authority (EFSA) and European Medicines Agency (EMA), from 24 countries (19 EU Member States and 5 countries associated to Horizon Europe).